Whether we refer to his deep-seated honesty of purpose or investment of one’s skills and efforts to produce the finest result, Chester M. Edelmann belonged to the best among us. He was born in New York City in 1930. His father was an accountant, and his mother a teacher. From one he probably inherited the compulsion for the exact, and from the other the tenacity, the determination. But his role model was his grandfather, nicknamed “Doc”; he practiced general medicine in Upper Manhattan. Chet went to Columbia College and then to Washington University in St. Louis, leaving behind his sweetheart, Norma. After the second year of medical school, he returned to New York City to finish medical school at Cornell University and get married. Set on a general pediatric practice, he jumped on the opportunity to move to the Bronx Municipal Hospital Center, the teaching hospital of the newly created Albert Einstein College of Medicine, where Henry Barnett moved from Cornell to assume the Chairmanship of the Department of Pediatrics. He became Chief Resident, and thereafter accepted a position in nephrology with Henry Barnett. A disputed topic at the time was the protein content of infants’ formulas. In a landmark article, published in the Journal of Clinical Investigation, Edelmann and his colleagues demonstrated that a high protein intake lead not only to an increase in urea and water excretion, but also to an increase in concentration capacity that almost wiped out the difference previously noted between infants and children.
In 1959, Chet was called to fulfill his patriotic duty. For the ensuing two years, he served as Staff Pediatrician at the U.S. Naval Hospital, in Portsmouth, VA. At the time of discharge, Chet reached the rank of Lieutenant Commander. It was already known at the time that values of blood pH and bicarbonate in young infants are lower than in older subjects. This improperly called “physiologic acidosis” of infancy was attributed to renal immaturity, on the assumption that the kidney cannot excrete into the urine a quantity of acid equal to that produced metabolically. The work of Robert Winters and others has shown that growth results in the gain of base, as alkaline bone salts are being laid down. These observations prompted Chester Edelmann, and his collaborators (Soriano, Boichis, Acosta, Stark and Gruskin) to study the response of infants and children to ammonium chloride acidosis. The rates of excretion of titratable acid and ammonium were somewhat different in infants and children, but net acid secretion, was not significantly different in the two groups. Thus, it was demonstrated that the ability of the infant to dispose of an acid load was adequate. When Edelmann et all determined the bicarbonate threshold in infants, they found it to be lower than in adults, at about 22 mmoles per liter. Moreover, the study of the renal threshold led to the identification of proximal renal tubular acidosis.
Armed with the tools required to study the function of discrete nephron segments, Edelmann and his co-workers published in fast succession a number of articles dealing with various aspects of developmental renal physiology or pathophysiology. This flurry of publications catapulted the Division of Pediatric Nephrology at Einstein to the top of the heap. In 1969, Chet was elected into the Society of Clinical Investigation, a distinguished fraternity almost exclusively reserved to internists. By than he was the Chief of the Division of Nephrology, an Associate Professor of Pediatrics, a member of the Society for Pediatric Research, and a recipient of an NIH Research Career Development Award. In 1972, Chet received the Mead Johnson Award conferred by the American Academy of Pediatrics. That same year, Henry Barnett became Associate Dean and, shortly thereafter, Chet Edelmann succeeded him as Chairman of the Department of Pediatrics at the Albert Einstein College of Medicine. The first nephrology treatise was edited by Maurice Strauss and Louis Welt in which Chet wrote a chapter on pediatric nephrology. It numbered 12 printed pages. Somebody in the publishing house of Little Brown apparently liked the chapter and approached Chet with the proposal to write a “small book” dedicated exclusively to pediatric nephrology. The year was 1976. At the time, Chet was chairing not only the Department, but was also a member of the NIH Medicine B Study Section, who’s Chairman he became one year later. And yet, he accepted to serve as editor of the first “large book” of pediatric nephrology. The amount of work was monumental, but so was the product. The book won the Technical and Scientific Award in the Field of Medicine from the Association of American Publishers, and became the standard of reference for those working in the field of pediatric nephrology.
In 1980, Chet left the Chairmanship to become Associate Dean. As expected, his new responsibilities have often kept him away from the Division and the Department in which he grew and which he nurtured. In the ancient world, teachers were rewarded in gold. So was Chet. At the 33rd Meeting of the New Orleans Medical Assembly he received a Rex doubloon (a Spanish gold coin no longer minted) as expression of appreciation for the lecture he gave. The American Society of Pediatric Nephrology and the Academy of Pediatrics, Section on Nephrology, honored Chet with the Founder’s and the Henry Barnett Awards, respectively. These tributes carry the sentiments of hundreds of people who have benefited from the many contributions he made to academic pediatrics and pediatric nephrology, and most importantly, to our Society.
Chet is survived by his adoring wife of 60 years, Norma, three loving children: John, Christopher, and Kathy and his granddaughter, Jessica, he is also survived by his sister, Maida Heitner, and her family. He is the son of the late Nannette Lenore Edelmann and Chester Monroe Edelmann, Sr. Chet was a true Renaissance man; a lover of languages and their usage: a concert level pianist; a faithful patron of opera, the theatre and the philharmonic. He created fine furniture, was a loyal Mets fan, and enjoyed simple beauty. He was devoted to his wife and family, his patients, his church, science, his community and his country. He believed in excellence, honesty, integrity and above all, compassion. Chet was a rare man, contemplative, yet effective, who quietly found success in the improved health of his patients, in the happiness of his children and in the achievement of his students and colleagues. Chet touched the lives of countless people in many countries worldwide and will be missed by all, but primarily by his wife and children.
Dr. Harry Lieberman, the husband of Dr. Ellin Lieberman, informed me that Ellin passed away peacefully after a long illness in South Pasadena,California. The older generation of pediatric nephrologists, such as myself,knew Ellin as a teacher, writer of one of the first pediatric nephrology textbooks, and a compassionate social activist with a global view.
On a personal note, I was contacted by Ellin soon after hurricane Katrina. She and Harry had raised funds in their community to help the children with ESRD and chronic kidney disease in the New Orleans area. Many of these families had lost their homes and material possessions and have not yet recovered. Ellin and Harry’s yearly fundraising has since continued and has, for instance, enabled us to send disadvantaged kids with kidney disease to summer camp. I am told by Harry that Ellin’s request was for the fundraising to continue after her passing and she had asked donations in her memory to be made to the two causes listed below.
The pediatric nephrology community will miss Ellin.
Matti Vehaskari, MD, PhD
Professor of Pediatrics
Children’s Hospital and LSU Health Sciences Center
Ellin requested that donations in her memory be made to:
Ellin Lieberman Scholarship Fund
Mail to: Pasadena Community Foundation
260 S. Los Robles Ave, Suite 119
Pasadena, CA 91101
National Kidney Foundation of Louisiana ’for Childrens Hospital Renal Unit’
Mail to: NKF of Louisiana
8200 Hampson St., Suite 425
New Orleans, LA 70118
Bruce Tune, MD, who founded the Division of Pediatric Nephrology at the Stanford University School of Medicine, died June 25 at his home in Palo Alto of complications of Parkinson’s disease. He was 71.
Tune arrived at Stanford as an undergraduate and stayed nearly his entire career, playing many leadership roles at the School of Medicine. Between 1991 and 1993, he was acting chair of the Department of Pediatrics. In the early 1990s, Tune was instrumental in launching the pediatric kidney transplant program at Lucile Packard Children’s Hospital, which is now among the most successful organ transplant programs in the world. He was known for compassion and dedication to his patients, gravely ill children suffering from a wide variety of kidney diseases.
“He was the epitome of a true bedside doctor,” said Oscar Salvatierra, MD, the surgeon Tune helped recruit to Packard Children’s to start the kidney transplant program. “He would spend whatever time was necessary with a patient, and especially with patients’ parents, to make sure they were well-informed. He endeared himself to the families because, in tough situations, he was there for them.”
Tune single-handedly ran the Division of Pediatric Nephrology for many years, recalled Packard Children’s neonatologist Philip Sunshine, MD, who knew Tune well. “He took care of all those kids himself,” Sunshine said. When Tune was himself hospitalized for a serious respiratory infection in the 1970s, he ran the division from his hospital bed while he recovered, Sunshine said.
Tune was born Aug. 26, 1939, in New York City. His family moved to Los Angeles when he was a small child. Tune came to Palo Alto to attend Stanford, earning his bachelor’s degree and then graduating from the School of Medicine in 1965. After an internship at Strong Memorial Hospital in Rochester, N.Y., and a residency in pediatrics at Stanford, Tune moved to Washington, D.C. in 1967 to work at the National Institutes of Health. There he met Nancy Doolittle, who soon became his wife. After their marriage in 1969, the couple returned to California so that Tune could assume the position of chief resident in pediatrics at Stanford. A faculty appointment soon followed.
As a faculty member at the School of Medicine, Tune was known for his teaching skills. Tune’s departmental colleagues honored him for several years with the Bruce Tune Award, established in the 1970s for the house officer who had made the best diagnosis during the previous year.
In addition to his enthusiasm for clinical care, Tune enjoyed the scientific discovery process. “I knew Bruce as an astoundingly bright scientific physician, one who could get to the central aspect of both science and disease with a few insightful questions and observations,” said his longtime colleague and close friend Irving Weissman, MD, professor of pathology and of developmental biology.
Away from his job, Tune enjoyed spending time with his family, including daughter Sara, now of Toronto, and son Steve, now of Portland, Ore. Tune was a skilled photographer; he enjoyed music, and he and Nancy grew prize-winning roses at their Palo Alto home.
“I first met Bruce when he recruited me to come to Stanford in 1997,” said Steve Alexander, MD, Stanford’s current Pediatric Nephrology Division Chief. “By that time he had been ill with Parkinson’s for almost a decade, and the disease had begun to take its toll.” Despite declining health, Tune continued to see patients in clinic every week and participated in conferences and meetings for another two years.
“I will remember Bruce as a gentle soul who had a kind word for everyone,” concluded Alexander. ” His soft-spoken advice seemed always to ring true. He was a gifted clinical pediatric nephrologist who understood the course and management of childhood nephrosis better than anyone I have known.”
Throughout his career, Tune always wanted to help others succeed, added Salvatierra. “He was there for everyone who needed him — patients, parents, medical students and residents, the Department of Pediatrics when they needed an acting chair. Professionally, his heart and soul was all Stanford.”
In addition to his wife, two children and grandchild, Tune is survived by his mother, Sylvia Newman Tune of Orange, Calif. The family asked that anyone wishing to make donations in Tune’s memory consider giving to the American Parkinson Disease Association.
The Department of Pediatrics is planning a memorial service, although details are still being arranged.
Dr. Michael Linshaw died at home on December 31, 2010 after a long illness, which he faced gallantly and with equanimity, which was his style. His loving family was present throughout his illness and at his side as he passed away.
Mike was a beloved physician, and we will greatly miss him, as will his many colleagues and patients around the world.
Mike had a long and distinguished career in pediatric nephrology as a clinician, teacher, and scientist; he was a unique person. He focused his work on the human aspects of medicine, positively influencing the lives of many children and their families, mentoring numerous young doctors, and conducting research that influenced the standard of care.
Beyond medicine, Mike was an accomplished classical pianist, chess player, bird watcher, and nature photographer. Those of us who came to know him—whether as family, friend, colleague, student, patient or just fellow traveler— were often wowed by his combination of joy, knowledge, compassion, and ethics. Mike cherished and celebrated life in his kind, quiet, and humorous way, even as he was increasingly challenged by his struggle with his illness. But even as his physical situation became insoluble, he remained vibrant and generous. He always reached out, asked those who had come to see him, “how are you?” and he asked it with genuine interest and caring.
Mike received his undergraduate degree in Philosophy at Franklin and Marshall College in 1962, and his MD from Hahnemann Medical College in 1966. After an internship at Maine Medical Center, he did his residency at the University of Vermont and then Mount Sinai Hospital in NY. He did a renal fellowship at St. Christopher’s Hospital for Children in Philadelphia, and an additional fellowship in renal physiology at Cornell Medical Center in NY. Mike was first a faculty member at the University of Kansas and then at the University of Connecticut, Tufts University, and for the past ten years at Harvard Medical School and MassGeneral Hospital for Children at MGH.
The son of the late Charles and Emily Linshaw, he was predeceased by his brother, Jack, and is survived by his loving wife Diane and three sons, Charles, Andrew and David. In lieu of flowers, please send donations in his memory to the Department of Pediatrics, MassGeneral Hospital for Children, 55 Fruit Street, Boston, MA 02114-2622.
The pediatric nephrology community has lost one of its stars. Juan Rodríguez Soriano was born on March 5, 1933 in Barcelona were he was raised and pursued his education up to and including the medical degree. After several years of general pediatric training at the Clinical Hospital of Barcelona, he won a scholarship at Hôpital des Enfants Malades, and arrived in Paris in October 1959. There, under the chairmanship of Prof. Pierre Royer, pediatricians from anywhere in the world had the unique opportunity to take a course devoted exclusively to the diagnosis and treatment of kidney diseases in children. At the time, in the adjacent Hôpital Necker, in the department of Prof. Jean Hamburger, nephrology was being born as a specialty distinct from internal medicine. Relationships between the two services were very close, and the joint sessions of pathologic correlations, directed by Dr. Renée Habib, remained indelible in Juan’s memory.
During the ensuing years, the group of Dr. Henry L. Barnett, Chairman of Pediatrics at the Albert Einstein School of Medicine in New York, gained prominence in the field of renal pathophysiology. His student, Dr. Chester M. Edelmann, developed the Division of Pediatric Nephrology in the early 60’s, with a strong focus on the investigation of neonatal renal function. With the support of Prof Royer, Juan joined the group in January 1963 as one of its first fellows. The research performed during those years, to which Juan contributed, included the mechanisms of urinary acidification [1,2] and urinary concentration in the newborn , and the seminal description of proximal renal tubular acidosis [4,5].
Juan returned to Barcelona in 1967 and became Head of the Clinical Service at the Children’s Hospital Vall d’Hebron. There, he met Maria Jesus Vita, a pediatric radiologist, who became his wife and the mother of their three children. In 1970, he took charge of the Department of Pediatrics at the Hospital Universitario de Cruces, where he remained until his retirement in 2003. At de Cruces, he led a group of young pediatricians, many trained in the U.S., and promoted the training of pediatric subspecialists. His incredible breath of knowledge, teaching skills, analytical ability, and clinical expertise were recognized by all those who had the privilege to work with him. In the 70’s, 80’s and early 90’s, he continued researching and publishing on renal function tests (6-10) and various tubulopathies (11-17). From the middle of the 90’s he collaborated with Dr. Richard Lifton’s group, at Yale University, and with other investigators, in the search to identify the molecular basis of Bartter syndrome [18,19], renal tubular acidosis [20,21], familial hypomagnesemia with hypercalciuria and nephrocalcinosis[22,23],pseudohypoaldosteronism [24,25], and other genetic disorders. His scientific contributions are described in over 300 publications.
In September 1967 Juan was in Glasgow for the founding of the European Society of Pediatric Nephrology, under the chairmanship of Gavin Arneil. In December 1968 he attended the meeting of the International Society of Pediatric Nephrology in Guadalajara, Mexico, and one of the first meetings of the International Study of Kidney Disease in Children, chaired by Henry Barnett, in Puerto Vallarta. In 1973, Spanish pediatricians founded the Section of Pediatric Nephrology of the Spanish Association of Pediatrics, followed by the Spanish Pediatric Nephrology Association, of which Juan was president from 1976 to 1981. He held the Grand Cross of the Civil Order of Health, was an honorary member of the Spanish Association of Pediatrics, was councilor on the IPNA Board from 1990 to 1995, served for several years on the Editorial Board of the Spanish Annals of Pediatrics, and was a member of the Editorial Board of Pediatric Nephrology for two extended periods (1987-1992 and 1995-2002). He will be deeply missed.
Died on March 7, 2010 at the age of 88
Dr. Nancy Holland was the first pediatric nephrologist in the Commonwealth of Kentucky joining the faculty of the University of Kentucky in 1964. After serving as First Lieutenant in the Army Nurse Corp at Walter Reed Hospital in Washington, D.C., she graduated from the University of Louisville School of Medicine in 1954. She completed her fellowship training under Clark D. West in 1960 at the Children’s Hospital Reseacrh Foundation in Cincinnati and remained there as an Assistant Professor (1962-64). She was appointed Professor of Pediatrics and Director of Pediatric Nephrology at the University of Kentucky in 1972 and served in those capacities until her retirement in 1988. Dr. Holland was one of the initial members of our society, serving on the committee on dialysis and transplantation (1973) an the membership committee (1977-80) which she chaired in 1979-80. She had over 50 publications related to a wide variety of topics in pediatric nephrology. She was most passionately interested in urinary tract infection and reflux nephropathy. Her clinical expertise and advocacy for her patients was clearly apparent to medical students, residents and faculty colleagues at the University of Kentucky Medical Center in Lexington.
Dr. Holland is survived by her husband of 49 years, Dr. Charles Phillip Holland, her sister Anne Hinkle Baldwin, her sister-in-law, Sally Spears Hinkle, her 7 nieces and nephews and her eighteen great-nieces and great-nephews, all of whom felt her never failing love and encouragement.
Died on May 11, 2010
Dr. William J. Oliver passed away on May 11th at the age of 85. Dr. Oliver was one of the initial pediatric nephrologists to take the Board exam and participated in one of the first kidney transplants in Michigan. He initially came to the University of Michigan in 1953 for residency and rapidly rose to the rank of Professor at age 40 and was appointed Department Chairman in 1967. He served on numerous Pediatric and Kidney societies including Chairman of the Council on Pediatric Education of the AAP. His early kidney research examined catecholamines in patients with, and animal models of, nephrotic syndrome and he was able to convince one of us that nephrosis might be a defect of hormonal function rather than albumin metabolism. Subsequently, he became interested in renal function of indigenous South American peoples and continued to actively publish his work on uric acid and the Yanomama Indians up to 2008.
Renée Habib, one of the giants of Pediatric Nephrology, died on December 4, 2009, in Paris, France. Throughout her professional life as a physician and scientist, Mme. Habib demonstrated extraordinary insight and understanding regarding the pathology of kidney diseases and contributed to significant advances in the treatment of different disorders. Beyond her exceptional scientific contributions, however, she was also an outstanding teacher and mentor, devoted to training the next generation of clinicians and investigators across the globe. On a personal note, I had the great privilege and honor of working with and learning from her and she was one of my most influential mentors. Mme. Habib was instrumental in the establishment of Pediatric Nephrology as a discipline in scientific communities and institutions worldwide, and she touched the lives of countless faculty, students, and investigators, directly and indirectly, in her tireless efforts to expand the research scope and number of pediatric nephrologists internationally.
Mme. Habib was born August 26, 1924, in Casablanca, Morocco. She left Morocco after high school to pursue her university studies at the Faculty of Medicine of Paris, where she enrolled at the close of World War II, in October 1945. Certified in both Hematology (1950) and Pathology (1951), Mme. Habib received her Doctor of Medicine in 1954 with a thesis on renal polyarteritis nodosa. Intellectually gifted and scientifically innovative, she embarked on what proved a consistently groundbreaking research career in the field now known as Nephropathology. Through close collaboration with the Pediatric Nephrology Department at the Enfants Malades Hospital and with the Adult Renal Unit at the Necker Hospital in Paris, Mme. Habib studied thousands of patients with various nephropathologies, which enabled her to develop and propose an original classification of glomerular nephropathologies based on disease morphology. Her classification scheme is a classic body of work that is still accepted by all nephrologists and nephropathologists worldwide and has led to numerous advances in the diagnosis and treatment of multiple renal disorders. Having trained hundreds of physicians who for over four decades flocked to her laboratories from across the globe, many moving on to their own distinguished research careers and contributing to the worldwide dissemination of her concepts and methods, Mme. Habib was the creator and driving force of the “French School” of renal pathology.
Pediatric Nephrology has lost one its founders but she will remain a seminal figure in the scientific history and progress of our discipline. Her legacy will be appreciated and admired for generations to come.
Isidro Salusky, M.D.