Glomerular Diseases
Mesangial Deposits
Electron microscopy of a biopsy specimen in a patient with IgA nephropathy. Electron dense deposits can be identified in the mesangium (black arrows), which on immunofluorescence would have predominant or…
Read MorePerihilar FSGS
Perihilar variant of focal segmental glomerulosclerosis (FSGS). Hyaline deposition and sclerosis occur at the vascular pole of the glomerulus. This variant is believed to be a secondary form of FSGS,…
Read MoreGlomerulomegaly
A normal glomerulus (left) and hypertrophied glomerulus (glomerulomegaly, right). Glomerulomegaly is an adaptive response to decreased nephron number (e.g. prematurity) and/or increased demand (e.g. obesity). Patients with glomerulomegaly may have…
Read MoreSegmental glomerulosclerosis in IgA nephropathy
A patient with IgA nephropathy and associated segmental glomerulosclerosis. Images courtesy of Patrick Walker, MD.
Read MoreCrescents
A segmental (left, black arrow) and circumferential crescent (right) in a patient with IgA nephropathy. Images courtesy of Patrick Walker, MD.
Read MoreEndocapillary hypercellularity
A normal appearing glomerulus (left) compared to a glomerulus with endocapillary hypercellularity (right). Note the hypercellular capillary loop (red arrow) compared to the normal capillary lumens (black arrows). This histologic…
Read MoreImmunofluorescent staining in C3 glomerulopathy
Immunofluorescent staining pattern in a patient with C3 glomerulopathy. There is strong C3 staining in the capillary loops and mesangium. Immunoglobulin staining, such as IgG, is typically absent or at…
Read MoreDense deposit disease
Dense deposit disease on electron microscopy in a patient with C3 glomerulopathy. This lesion results from intramembranous transformation of the glomerular basement membrane by sausage-like, “osmiophilic” dense material. Images courtesy…
Read MoreMembranoproliferative glomerulonephritis
Membranoproliferative pattern of glomerular injury in a patient with C3 glomerulopathy. This pattern of injury typically has endocapillary proliferation, diffuse capillary wall thickening, increased mesangial matrix, and mesangial proliferation visible…
Read MoreFocal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) in a child presenting with nephrotic syndrome. Image courtesy of Joseph Gaut, MD PhD.
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