Mesangial Deposits

Electron microscopy of a biopsy specimen in a patient with IgA nephropathy. Electron dense deposits can be identified in the mesangium (black arrows), which on immunofluorescence would have predominant or…

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Dense deposit disease

Dense deposit disease on electron microscopy in a patient with C3 glomerulopathy. This lesion results from intramembranous transformation of the glomerular basement membrane by sausage-like, “osmiophilic” dense material. Images courtesy…

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Tubuloreticular inclusions in SLE nephritis

Tubuloreticular inclusions in a patient with diffuse proliferative SLE nephritis (SLE class IV). These subcellular structures (dark circular clusters) on transmission electron microscopy are localized to the cytoplasm of endothelial…

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